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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARFGEF1
All Species:
22.73
Human Site:
Y874
Identified Species:
62.5
UniProt:
Q9Y6D6
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6D6
NP_006412.2
1849
208767
Y874
E
E
Y
L
S
A
I
Y
N
E
I
A
G
K
K
Chimpanzee
Pan troglodytes
XP_519797
1849
208795
Y874
E
E
Y
L
S
A
I
Y
N
E
I
A
G
K
K
Rhesus Macaque
Macaca mulatta
XP_001096475
1849
208876
Y874
E
E
Y
L
S
A
I
Y
N
E
I
A
G
K
K
Dog
Lupus familis
XP_535095
1849
208810
Y874
E
E
Y
L
S
A
I
Y
N
E
I
A
G
K
K
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511437
1817
205305
Y842
E
E
Y
L
S
A
I
Y
N
E
I
A
G
K
K
Chicken
Gallus gallus
XP_418283
1537
173177
D668
Y
G
S
L
N
S
L
D
S
T
A
S
S
G
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002666513
1843
207765
Y877
E
E
Y
L
S
S
I
Y
D
E
I
A
G
K
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q42510
1451
162600
F582
D
P
K
K
G
L
E
F
L
Q
G
T
H
L
L
Baker's Yeast
Sacchar. cerevisiae
P11075
2009
226867
F1002
R
D
F
L
E
G
L
F
N
E
I
A
N
N
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.4
98.7
N.A.
N.A.
N.A.
N.A.
93
79.6
N.A.
73.5
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
100
99.6
99.2
N.A.
N.A.
N.A.
N.A.
95.2
81.5
N.A.
82.8
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
N.A.
N.A.
N.A.
100
6.6
N.A.
86.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
N.A.
N.A.
N.A.
100
40
N.A.
100
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.1
26
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.5
46.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
56
0
0
0
0
12
78
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
12
12
0
0
0
0
0
12
12
0
0
0
0
0
0
% D
% Glu:
67
67
0
0
12
0
12
0
0
78
0
0
0
0
12
% E
% Phe:
0
0
12
0
0
0
0
23
0
0
0
0
0
0
0
% F
% Gly:
0
12
0
0
12
12
0
0
0
0
12
0
67
12
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% H
% Ile:
0
0
0
0
0
0
67
0
0
0
78
0
0
0
12
% I
% Lys:
0
0
12
12
0
0
0
0
0
0
0
0
0
67
67
% K
% Leu:
0
0
0
89
0
12
23
0
12
0
0
0
0
12
12
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
12
0
0
0
67
0
0
0
12
12
0
% N
% Pro:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% Q
% Arg:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
12
0
67
23
0
0
12
0
0
12
12
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
12
0
12
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
12
0
67
0
0
0
0
67
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _